In respiratory intensive care unit, hemodnamic changes following extubation with or without bolus esmolol were evaluated in fourty two patients who underwent open heart surgery. They were divided into three groups. E0 group(no esmolol was given
before
extubation), E1 group(esmolol in a dose of 1.0mg/kg was given before extubation), and E1.5 group(esmolol in a dose of 1.5mg/kg was given before extubation).Number of patients in each group was fourteen, respectively. In E0 group, heart rate was
increased significantly(p<0.01) just after extubation compared to baseline. But, in E1 and E1.5 group, heart rate was unchanged significantly during extubation. The changes of heart rate due to extubation were significantly(P<0.05) different
between E0
and E1 group, E0 and E1.5 group but not different between E1 and E1.5 group. Systolic blood pressure was not changed during extubation in E0 E1 and E1.5 group and the changes of systolic blood pressure due to extubation were not different between
groups.
We may suggest that 1.0 mg/kg bolus esmolol attenuates cardiovascular responses to extubation and we should pay a special attention to the drug interaction of esmolol with other adrenergic blockers.
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